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Presenting our premium Recombinant Human MME protein, an essential tool for researchers focused on cancer studies. Neprilysin (CD10) is expressed in yeast, and this recombinant protein encompasses the extracellular domain (52-750aa), providing superior performance for a wide range of applications in cancer research. Engineered with an N-terminal 6xHis-tag, our Recombinant Human MME protein allows for seamless purification and detection. Boasting a purity of greater than 90% as determined by SDS-PAGE, you can confidently rely on the exceptional quality of this protein to enhance your cancer research endeavors. Available in both liquid and lyophilized powder formats, choose the most suitable form to meet your experimental needs and optimize your research workflow with our Recombinant Human MME protein.
Presenting our premium Recombinant Human MME protein, an essential tool for researchers focused on cancer studies. Neprilysin (CD10) is expressed in yeast, and this recombinant protein encompasses the extracellular domain (52-750aa), providing superior performance for a wide range of applications in cancer research.
Engineered with an N-terminal 6xHis-tag, our Recombinant Human MME protein allows for seamless purification and detection. Boasting a purity of greater than 90% as determined by SDS-PAGE, you can confidently rely on the exceptional quality of this protein to enhance your cancer research endeavors. Available in both liquid and lyophilized powder formats, choose the most suitable form to meet your experimental needs and optimize your research workflow with our Recombinant Human MME protein.
| Cat.No | ACP02565 | Target Name | MME |
|---|---|---|---|
| Target Synonyms | Atriopeptidase; CALLA; CD10; CD10 antigen; Common acute lymphocytic leukemia antigen; DKFZp686O16152; EC 3.4.24.11; Enkephalinase; EPN; Membrane metallo endopeptidase (neutral endopeptidase, CALLA, enkephalinase, enkephalinase); Membrane metallo endopeptidase (neutral endopeptidase, membrane-associated; SFE; Skin fibroblast elastase | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 52-750aa |
| Mol Weight | 81.8kDa | Protein Length | Extracellular Domain |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P08473 |
|---|
Uniprot Id
P08473
Target Species
Human
Target Name
MME
Target Full Name
Neprilysin
Target Function
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.
Target Involvement
Charcot-Marie-Tooth disease 2T (CMT2T); Spinocerebellar ataxia 43 (SCA43)
Target Subcellular Location
Cell membrane; Single-pass type II membrane protein.
Target Protein Families
Peptidase M13 family
Target Research Area
Cancer
Target Synonyms
Atriopeptidase; CALLA; CD10; CD10 antigen; Common acute lymphocytic leukemia antigen; DKFZp686O16152; EC 3.4.24.11; Enkephalinase; EPN; Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase); Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); Membrane metallo endopeptidase; Membrane metallo endopeptidase variant 1; Membrane metallo endopeptidase variant 2; Membrane metalloendopeptidase; Membrane metalloendopeptidase neutral endopeptidase enkephalinase; Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10 ; Membrane metalloendopeptidase variant 1; Membrane metalloendopeptidase variant 2; MGC126681; MGC126707; MME; NEP; NEP_HUMAN; Neprilysin; neprilysin-390; neprilysin-411; Neutral endopeptidase 24.11; Neutral endopeptidase; Neutral endopeptidase, membrane-associated; SFE; Skin fibroblast elastase
Target Background
The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
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