Recombinant Human Netrin receptor DCC (DCC), Truncated

Uniprot Id

P43146

Target Species

Human

Target Name

DCC

Target Full Name

Netrin receptor DCC

Target Function

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

Target Involvement

Mirror movements 1 (MRMV1); Gaze palsy, familial horizontal, with progressive scoliosis, 2 (HGPPS2)

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Immunoglobulin superfamily, DCC family

Target Tissue Specificity

Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.

Target Synonyms

Colorectal cancer related chromosome sequence 18; Colorectal cancer suppressor; CRC 18; CRC18; CRCR 1; CRCR1; DCC; DCC_HUMAN; Deleted in colorectal cancer protein; Deleted in colorectal carcinoma ; Immunoglobulin superfamily DCC subclass member 1; Netrin receptor DCC; Tumor suppressor protein DCC

Target Background

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.