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Recombinant Human Neudesin (NENF)

ACP09857

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP09857 Target NameNENF
FormLyophilized powderExpression SystemCustom Production. Please inquire and provide the desire expression system.
Expression Range32-172Protein LengthFull Length of Mature Protein
Purity>85% (SDS-PAGE)Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDQ9UMX5
Background Information
  • Uniprot Id

    Q9UMX5

  • Target Species

    Human

  • Target Name

    NENF

  • Target Full Name

    Neudesin

  • Target Function

    Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance.

  • Target Subcellular Location

    Secreted, extracellular space. Mitochondrion. Endoplasmic reticulum.

  • Target Protein Families

    Cytochrome b5 family, MAPR subfamily

  • Target Tissue Specificity

    Ubiquitously expressed with high expression in heart. Over-expressed in various tumors including carcinomas of the uterine cervix, lymphoma, colon, lung, skin and leukemia, as well as carcinoma of the breast.

  • Target Synonyms

    Cell growth inhibiting protein 47; Cell immortalization-related protein 2; CIR2; Nenf; NENF_HUMAN; Neudesin; Neuron derived neurotrophic factor; Neuron-derived neurotrophic factor; SCIRP10; SCIRP10 related protein; Secreted protein of unknown function; Spinal cord injury related protein 10; SPUF; SPUF protein

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