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| Cat.No | ACP10295 | Target Name | NGRN |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 16-291 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NPE2 |
|---|
Uniprot Id
Q9NPE2
Target Species
Human
Target Name
NGRN
Target Full Name
Neugrin
Target Function
Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.
Target Subcellular Location
Nucleus. Secreted. Mitochondrion membrane.
Target Protein Families
Neugrin family
Target Tissue Specificity
Expressed at high levels in heart, brain and skeletal muscle. In brain, mainly expressed in neurons rather than glial cells.
Target Synonyms
DSC92; FI58Gm; Mesenchymal stem cell protein DSC92; Neugrin; Neugrin neurite outgrowth associated ; Neurite outgrowth associated protein ; Neurite outgrowth-associated protein; Ngrn; NGRN_HUMAN; Spinal cord-derived protein FI58G
Target Background
Enables rRNA binding activity. Involved in positive regulation of mitochondrial translation. Located in several cellular components, including intercellular bridge; mitotic spindle; and nuclear body.
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