Recombinant Human Neurogenic locus notch homolog protein 2 (NOTCH2), Truncated

Uniprot Id

Q04721

Target Species

Human

Target Name

NOTCH2

Target Full Name

Neurogenic locus notch homolog protein 2

Target Function

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells.

Target Involvement

Alagille syndrome 2 (ALGS2); Hajdu-Cheney syndrome (HJCYS)

Target Subcellular Location

[Notch 2 extracellular truncation]: Cell membrane; Single-pass type I membrane protein.; [Notch 2 intracellular domain]: Nucleus. Cytoplasm.

Target Protein Families

NOTCH family

Target Tissue Specificity

Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.

Target Synonyms

AGS2; hN2; Motch B; N2; N2ECD; N2ICD; neurogenic locus notch homolog protein 2; NOTC2_HUMAN; Notch 2; Notch 2 intracellular domain; Notch Drosophila homolog 2; Notch homolog 2; Notch homolog 2 Drosophila; Notch2

Target Background

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.