Recombinant Human Neuroglobin (NGB)

Uniprot Id

Q9NPG2

Target Species

Human

Target Name

NGB

Target Full Name

Neuroglobin

Target Function

Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.

Target Subcellular Location

Perikaryon. Cytoplasm. Mitochondrion.

Target Protein Families

Globin family

Target Tissue Specificity

Predominantly expressed in brain, the strongest expression is seen in the frontal lobe, the subthalamic nucleus and the thalamus.

Target Research Area

Transport

Target Synonyms

Neuroglobin; NGB; NGB_HUMAN

Target Background

This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions.