Recombinant Human Neurotensin receptor type 1 (NTSR1), Truncated

Uniprot Id

P30989

Target Species

Human

Target Name

NTSR1

Target Full Name

Neurotensin receptor type 1

Target Function

G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Membrane raft.

Target Protein Families

G-protein coupled receptor 1 family, Neurotensin receptor subfamily, NTSR1 sub-subfamily

Target Tissue Specificity

Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain.

Target Synonyms

NTSR1; NTRR; Neurotensin receptor type 1; NT-R-1; NTR1; High-affinity levocabastine-insensitive neurotensin receptor; NTRH

Target Background

Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion.