Recombinant Human Neutrophil cytosol factor 1 (NCF1)

Uniprot Id

P14598

Target Species

Human

Target Name

NCF1

Target Full Name

Neutrophil cytosol factor 1

Target Function

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).

Target Involvement

Granulomatous disease, chronic, cytochrome-b-positive 1, autosomal recessive (CGD1)

Target Subcellular Location

Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side.

Target Tissue Specificity

Detected in peripheral blood monocytes and neutrophils (at protein level).

Target Synonyms

47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NADPH oxidase organizer 2; NCF 47K; NCF-1; NCF-47K; Ncf1; NCF1_HUMAN; Neutrophil cytosol factor 1; Neutrophil cytosolic factor 1; neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1); Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox organizing protein 2; Nox-organizing protein 2; NOXO2; p47 phox; p47-phox; SH3 and PX domain containing protein 1A; SH3 and PX domain-containing protein 1A; SH3PXD1A

Target Background

The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.