Recombinant Human NF-kappa-B inhibitor-like protein 1 (NFKBIL1)

Uniprot Id

Q9UBC1

Target Species

Human

Target Name

NFKBIL1

Target Full Name

NF-kappa-B inhibitor-like protein 1

Target Function

Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli.

Target Involvement

Rheumatoid arthritis (RA)

Target Subcellular Location

Nucleus. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus.

Target Tissue Specificity

Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.

Target Synonyms

NFKBIL1; IKBL; NF-kappa-B inhibitor-like protein 1; Inhibitor of kappa B-like protein; I-kappa-B-like protein; IkappaBL; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

Target Background

This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene.