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Recombinant Human NF-kappa-B-repressing factor (NKRF)

ACP21385

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Specifications

Cat.No	ACP21385	Target Name	NKRF
Target Synonyms	NKRF; ITBA4; NRF; NF-kappa-B-repressing factor; NFkB-repressing factor; Protein ITBA4; Transcription factor NRF	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-690
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	O15226

Background Information

Uniprot Id

O15226
Target Species

Human
Target Name

NKRF
Target Full Name

NF-kappa-B-repressing factor
Target Function

Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.
Target Subcellular Location

Nucleus, nucleolus.
Target Tissue Specificity

Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney.
Target Research Area

Cell Biology
Target Synonyms

NKRF; ITBA4; NRF; NF-kappa-B-repressing factor; NFkB-repressing factor; Protein ITBA4; Transcription factor NRF
Target Background

This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants.

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Recombinant Human NF-kappa-B-repressing factor (NKRF)

Specifications

Immunogen Information

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