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| Cat.No | ACP14560 | Target Name | NFATC2IP |
|---|---|---|---|
| Target Synonyms | 45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; cytoplasmic 2-interacting protein; ESC2; NF2IP_HUMAN; NFAT-interacting protein, 45-KD; NFATC2-interacting protein; Nfatc2ip; NIP45; Nuclear factor of activated T-cells; Nuclear factor of activated T-cells, calcineurin-dependent 2 interacting protein; RAD60, cytoplasmic, cytoplasmic 2-interacting protein; nuclear factor of activated T-cells | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-419 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8NCF5 |
|---|
Uniprot Id
Q8NCF5
Target Species
Human
Target Name
NFATC2IP
Target Full Name
NFATC2-interacting protein
Target Function
In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9.
Target Subcellular Location
Nucleus. Cytoplasm.
Target Synonyms
45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; cytoplasmic 2-interacting protein; ESC2; NF2IP_HUMAN; NFAT-interacting protein, 45-KD; NFATC2-interacting protein; Nfatc2ip; NIP45; Nuclear factor of activated T-cells; Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein; RAD60
Target Background
Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus.
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