Recombinant Human NKG2D ligand 1 (ULBP1)

Uniprot Id

Q9BZM6

Target Species

Human

Target Name

ULBP1

Target Full Name

UL16-binding protein 1

Target Function

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Target Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum.

Target Protein Families

MHC class I family

Target Tissue Specificity

Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.

Target Synonyms

Alcan beta; ALCAN-beta; N2DL-1; N2DL1; N2DL1_HUMAN; NKG2D ligand 1; NKG2D ligand 1 precursor; NKG2DL1; RAET1I; Retinoic acid early transcript 1I; UL16; UL16 binding protein 1; UL16-binding protein 1; ULBP1

Target Background

The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene.