Recombinant Human NMDA receptor-regulated protein 2 (NARG2), Truncated

Uniprot Id

Q659A1

Target Species

Human

Target Name

ICE2

Target Full Name

Little elongation complex subunit 2

Target Function

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.

Target Subcellular Location

Nucleus. Note=Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Translocates in the LEC complex to Cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.

Target Protein Families

ICE2 family

Target Tissue Specificity

Expressed at low levels in lung and testis.

Target Synonyms

ICE2; BRCC1; NARG2; UNQ3101/PRO10100; Little elongation complex subunit 2; Interactor of little elongator complex ELL subunit 2; NMDA receptor-regulated protein 2

Target Background

This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation. The encoded protein and other LEC components have been shown to localize to Cajal bodies, which are sites of ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene have been identified on chromosomes 3 and 4.