Recombinant Human Nocturnin (CCRN4L)

Uniprot Id

Q9UK39

Target Species

Human

Target Name

NOCT

Target Full Name

Nocturnin

Target Function

Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH. Shows a small preference for NADPH over NADP(+). Represses translation and promotes degradation of target mRNA molecules. Plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos

Target Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Mitochondrion.

Target Protein Families

CCR4/nocturin family

Target Tissue Specificity

Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue.

Target Synonyms

NOCT; CCR4; CCRN4L; NOCNocturnin; EC 3.1.3.-; Carbon catabolite repression 4-like protein

Target Background

The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector.