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Recombinant Human Noelin-2 (OLFM2)

ACP20801

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Specifications

Cat.No	ACP20801	Target Name	OLFM2
Target Synonyms	Neuronal olfactomedin related ER localized protein 2; NOE2; NOE2_HUMAN; Noelin 2; Noelin-2; NOELIN2; NOELIN2 V1; Olfactomedin 2; Olfactomedin-2; OlfC; Olfm2	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	21-454
Protein Length	Full Length of Mature Protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	O95897

Background Information

Uniprot Id

O95897
Target Species

Human
Target Name

OLFM2
Target Full Name

Noelin-2
Target Function

Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes. Plays a role in AMPAR complex organization. Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling.
Target Subcellular Location

Secreted. Cell junction, synapse. Membrane. Nucleus. Cytoplasm.
Target Tissue Specificity

Expressed in aortic smooth muscle (at protein level). In the fetus, expressed in the brain and ocular tissues including lens vesicle and optic cup.
Target Synonyms

Neuronal olfactomedin related ER localized protein 2; NOE2; NOE2_HUMAN; Noelin 2; Noelin-2; NOELIN2; NOELIN2 V1; Olfactomedin 2; Olfactomedin-2; OlfC; Olfm2

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Recombinant Human Noelin-2 (OLFM2)

Specifications

Immunogen Information

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