Recombinant Human NPC intracellular cholesterol transporter 1 (NPC1), Truncated

Cat.No	ACP01869	Target Name	NPC1
Target Synonyms	Niemann-Pick C1 protein	Form	Liquid or Lyophilized powder
Expression System	Yeast	Expression Range	23-261aa
Mol Weight	30.2 kDa	Protein Length	Partial
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP01869

Target Name

NPC1

Target Synonyms

Niemann-Pick C1 protein

Form

Liquid or Lyophilized powder

Expression System

Yeast

Expression Range

23-261aa

Mol Weight

30.2 kDa

Protein Length

Partial

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O15118

Background Information

Uniprot Id

O15118
Target Species

Human
Target Name

NPC1
Target Full Name

NPC intracellular cholesterol transporter 1
Target Function

Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).; (Microbial infection) Acts as an endosomal entry receptor for ebolavirus.
Target Involvement

Niemann-Pick disease C1 (NPC1)
Target Subcellular Location

Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Target Protein Families

Patched family
Target Research Area

Cardiovascular, Transcription
Target Synonyms

Niemann Pick C1 protein precursor; Niemann Pick disease, type C1; Niemann-Pick C1 protein; NPC; NPC1; NPC1_HUMAN
Target Background

This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.

Recombinant Human NPC intracellular cholesterol transporter 1 (NPC1), Truncated

Specifications

Immunogen Information

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