Recombinant Human Nuclear pore complex protein Nup50 (NUP50)

Uniprot Id

Q9UKX7

Target Species

Human

Target Name

NUP50

Target Full Name

Nuclear pore complex protein Nup50

Target Function

Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with regulatory proteins of cell cycle progression including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B.

Target Subcellular Location

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side.

Target Tissue Specificity

Ubiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver.

Target Synonyms

50 kDa nucleoporin; NPAP60 ; NPAP60L; Nuclear pore associated protein 60L; Nuclear pore complex protein Nup50; Nuclear pore-associated protein 60 kDa-like; Nucleoporin 50; Nucleoporin 50kDa; Nucleoporin Nup50; Nup50; NUP50_HUMAN; PRO1146

Target Background

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene.