Recombinant Human Nucleobindin-2 protein (NUCB2)

Uniprot Id

P80303

Target Species

Human

Target Name

NUCB2

Target Full Name

Nucleobindin-2

Target Function

Calcium-binding protein which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3.; Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance.

Target Subcellular Location

Golgi apparatus. Membrane; Peripheral membrane protein. Cytoplasm. Secreted. Endoplasmic reticulum. Nucleus envelope. Note=Golgi retention is mediated by its N-terminal region.; [Nesfatin-1]: Secreted.

Target Protein Families

Nucleobindin family

Target Tissue Specificity

Predominantly expressed in spleen, testis and normal stomach.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

DNA binding protein NEFA; DNA-binding protein NEFA; Gastric cancer antigen Zg4; HEL S 109; NEFA; Nefastin 1; Nefastin-1; Nefastin1; Nucb2; NUCB2_HUMAN; Nucleobindin 2; Nucleobindin-2; Nucleobinding 2; Prepronefastin; Prepronesfatin

Target Background

This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains.