Recombinant Human Nucleolar GTP-binding protein 1 (GTPBP4)

Uniprot Id

Q9BZE4

Target Species

Human

Target Name

GTPBP4

Target Full Name

GTP-binding protein 4

Target Function

Involved in the biogenesis of the 60S ribosomal subunit.

Target Subcellular Location

Nucleus, nucleolus.

Target Protein Families

TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family, NOG subfamily

Target Synonyms

Chronic renal failure gene protein; CRFG ; G protein binding protein CRFG; GTP binding protein 4; GTP-binding protein NGB; Gtpbp4; NGB ; NOG1 ; NOG1_HUMAN; Nucleolar GTP binding protein 1; Nucleolar GTP-binding protein 1

Target Background

GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.