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This Human NME2 recombinant protein was produced in E.coli, where the gene sequence encoding Human NME2 (2-152aa) was expressed with the N-terminal 10xHis tag and C-terminal Myc tag. The purity of this NME2 protein was greater than 85% by SDS-PAGE.NME2 is an enzyme that catalyzes the phosphorylation of nucleoside monophosphates, converting them into nucleoside diphosphates. This is an important biochemical process involved in cellular energy metabolism and nucleotide synthesis. NME2 plays a critical role in various cellular biological processes. It is involved in DNA synthesis, RNA synthesis, cell cycle regulation, and cell signal transduction. Additionally, NME2 is associated with cellular antioxidant defense and apoptosis. Furthermore, NME2 is of significant interest in cancer biology. Some studies suggest that NME2 plays a role in tumor suppression as it can regulate the cell cycle and apoptosis. Therefore, abnormal expression of NME2 is associated with the development and progression of various cancers, including breast cancer and prostate cancer.
This Human NME2 recombinant protein was produced in E.coli, where the gene sequence encoding Human NME2 (2-152aa) was expressed with the N-terminal 10xHis tag and C-terminal Myc tag. The purity of this NME2 protein was greater than 85% by SDS-PAGE.NME2 is an enzyme that catalyzes the phosphorylation of nucleoside monophosphates, converting them into nucleoside diphosphates. This is an important biochemical process involved in cellular energy metabolism and nucleotide synthesis. NME2 plays a critical role in various cellular biological processes. It is involved in DNA synthesis, RNA synthesis, cell cycle regulation, and cell signal transduction. Additionally, NME2 is associated with cellular antioxidant defense and apoptosis. Furthermore, NME2 is of significant interest in cancer biology. Some studies suggest that NME2 plays a role in tumor suppression as it can regulate the cell cycle and apoptosis. Therefore, abnormal expression of NME2 is associated with the development and progression of various cancers, including breast cancer and prostate cancer.
| Cat.No | ACP03408 | Target Name | NME2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-152aa | Mol Weight | 24.2 kDa |
| Protein Length | Partial | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P22392 |
|---|
Uniprot Id
P22392
Target Species
Human
Target Name
NME2
Target Full Name
Nucleoside diphosphate kinase B
Target Function
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not. Exhibits histidine protein kinase activity.
Target Subcellular Location
Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle.
Target Protein Families
NDK family
Target Tissue Specificity
Isoform 1 and isoform 3 are ubiquitously expressed.
Target Research Area
Neuroscience
Target Synonyms
C myc purine binding transcription factor PUF; C myc transcription factor; C-myc purine-binding transcription factor PUF; epididymis secretory sperm binding protein Li 155an; HEL-S-155an; Histidine protein kinase NDKB; MGC111212; MGC2212; NDK B; NDKB; NDKB_HUMAN; NDP kinase B; NDPK B; NDPKB; NM23 H2; nm23-H2; NM23B; NME/NM23 nucleoside diphosphate kinase 2; nme2; Non metastatic cells 2; protein (NM23B) expressed in; non-metastatic cells 2; protein (NM23) expressed in; Nucleoside diphosphate kinase B; Nucleotide diphosphate kinase B; PUF
Target Background
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product.
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