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| Cat.No | ACP20900 | Target Name | OBSL1 |
|---|---|---|---|
| Target Synonyms | KIAA0657; Obscurin-like protein 1; OBSL1; OBSL1_HUMAN | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O75147 |
|---|
Uniprot Id
O75147
Target Species
Human
Target Name
OBSL1
Target Full Name
Obscurin-like protein 1
Target Function
Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons.
Target Involvement
3M syndrome 2 (3M2)
Target Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Golgi apparatus. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons (PubMed:21572988).
Target Tissue Specificity
Widely expressed, with predominant levels found in the heart.
Target Synonyms
KIAA0657; Obscurin-like protein 1; OBSL1; OBSL1_HUMAN
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