Recombinant Human Opioid growth factor receptor (OGFR)

Uniprot Id

Q9NZT2

Target Species

Human

Target Name

OGFR

Target Full Name

Opioid growth factor receptor

Target Function

Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.

Target Subcellular Location

Cytoplasm. Nucleus. Note=The OGF/OGFR complex is probably translocated to the nucleus.

Target Protein Families

Opioid growth factor receptor family

Target Tissue Specificity

Highly expressed in the heart and liver, moderately in skeletal muscle and kidney and to a lesser extent in brain and pancreas. Expressed in fetal tissues including liver and kidney.

Target Research Area

Cell Biology

Target Synonyms

7 60 protein; HGNC:15768; Met enkephalin receptor; OGFr; OGFR_HUMAN; Opioid growth factor receptor; Protein 7-60; Zeta Opioid Receptor; Zeta type opioid receptor; Zeta-type opioid receptor

Target Background

The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported.