Recombinant Human Origin recognition complex subunit 6 (ORC6)

Uniprot Id

Q9Y5N6

Target Species

Human

Target Name

ORC6

Target Full Name

Origin recognition complex subunit 6

Target Function

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

Target Involvement

Meier-Gorlin syndrome 3 (MGORS3)

Target Subcellular Location

Nucleus.

Target Protein Families

ORC6 family

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

ORC 6; Orc6; ORC6_HUMAN; ORC6L; Origin recognition complex subunit 6; origin recognition complex subunit 6 homolog like; origin recognition complex subunit 6 homolog like (yeast); origin recognition complex subunit 6 like (yeast)

Target Background

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.