Recombinant Human Outer dense fiber protein 1 (ODF1)

Uniprot Id

Q14990

Target Species

Human

Target Name

ODF1

Target Full Name

Outer dense fiber protein 1

Target Function

Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

Target Tissue Specificity

Testis.

Target Synonyms

Cancer/testis antigen 133; CT133; HSPB10; ODF; Odf1; ODF2; ODF27; ODFP; ODFP1_HUMAN; ODFPG; ODFPGA; ODFPGB; Outer dense fiber of sperm tails 1; Outer dense fiber of sperm tails, 27 kD; Outer dense fiber protein 1; RT7; SODF

Target Background

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein.