Recombinant Human P2X purinoceptor 3 (P2RX3), Truncated

Uniprot Id

P56373

Target Species

Human

Target Name

P2RX3

Target Full Name

P2X purinoceptor 3

Target Function

Receptor for ATP that acts as a ligand-gated cation channel. Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

P2X receptor family

Target Synonyms

ATP receptor; MGC129956; P2rx3; P2RX3_HUMAN; P2X purinoceptor 3; P2X receptor subunit 3; P2X3; Purinergic receptor; Purinergic receptor P2X ligand gated ion channel 3; Purinergic receptor P2X3; Purinoceptor P2X3

Target Background

This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia.