Recombinant Human Paired box protein Pax-8 (PAX8)

Uniprot Id

Q06710

Target Species

Human

Target Name

PAX8

Target Full Name

Paired box protein Pax-8

Target Function

Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.

Target Involvement

Hypothyroidism, congenital, non-goitrous, 2 (CHNG2)

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Expressed in the excretory system, thyroid gland and Wilms tumors.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

OTTHUMP00000158659; OTTHUMP00000158660; OTTHUMP00000203723; OTTHUMP00000203724; Paired box 8; Paired box gene 8; paired box homeotic gene 8; Paired box protein Pax 8; Paired box protein Pax-8; Paired domain gene 8; PAX 8; PAX8; PAX8_HUMAN

Target Background

This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.