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The expression region of this recombinant Human PNMA1 covers amino acids 1-353. The expected molecular weight for the PNMA1 protein is calculated to be 46.8 kDa. The PNMA1 protein was expressed in e.coli. The PNMA1 coding gene included the N-terminal 10xHis-B2M-JD tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant PNMA1 protein in following stages of expression and purification.Paraneoplastic antigen Ma1 (PNMA1) is a protein associated with paraneoplastic neurological disorders (PND), a group of rare conditions where the immune system mistakenly targets normal neural tissues in response to an underlying tumor, often affecting the nervous system. PNMA1 is expressed in the brain and is associated with onconeural antibodies found in patients with PND. Investigations into the molecular pathways involving PNMA1 contribute to the broader understanding of autoimmune reactions associated with cancer and may offer insights into novel treatment strategies for paraneoplastic neurological disorders.
The expression region of this recombinant Human PNMA1 covers amino acids 1-353. The expected molecular weight for the PNMA1 protein is calculated to be 46.8 kDa. The PNMA1 protein was expressed in e.coli. The PNMA1 coding gene included the N-terminal 10xHis-B2M-JD tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant PNMA1 protein in following stages of expression and purification.Paraneoplastic antigen Ma1 (PNMA1) is a protein associated with paraneoplastic neurological disorders (PND), a group of rare conditions where the immune system mistakenly targets normal neural tissues in response to an underlying tumor, often affecting the nervous system. PNMA1 is expressed in the brain and is associated with onconeural antibodies found in patients with PND. Investigations into the molecular pathways involving PNMA1 contribute to the broader understanding of autoimmune reactions associated with cancer and may offer insights into novel treatment strategies for paraneoplastic neurological disorders.
| Cat.No | ACP02028 | Target Name | PNMA1 |
|---|---|---|---|
| Target Synonyms | 37 kDa neuronal protein; MA1; Neuron- and testis-specific protein 1; Paraneoplastic antigen Ma1; paraneoplastic neuronal antigen MA1; Pnma1; PNMA1_HUMAN | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-353aa |
| Mol Weight | 46.8 kDa | Protein Length | Full length |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8ND90 |
|---|
Uniprot Id
Q8ND90
Target Species
Human
Target Name
PNMA1
Target Full Name
Paraneoplastic antigen Ma1
Target Subcellular Location
Nucleus, nucleolus. Note=In tumor cells, it is cytoplasmic.
Target Protein Families
PNMA family
Target Tissue Specificity
Testis- and brain-specific. In some cancer patients, specifically expressed by paraneoplastic tumor cells.
Target Research Area
others
Target Synonyms
37 kDa neuronal protein; MA1; Neuron- and testis-specific protein 1; Paraneoplastic antigen Ma1; paraneoplastic neuronal antigen MA1; Pnma1; PNMA1_HUMAN
Target Background
This gene encodes a neuron- and testis-specific protein that is also expressed in some paraneoplastic syndromes affecting the nervous system. Some patients with neurologic disorders develop antibodies against the protein encoded by this gene. The identification of the antineuronal antibodies in the sera of these patients has facilitated the diagnosis of paraneoplastic neurological disorders and the early detection of the associated tumors.
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