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| Cat.No | ACP17195 | Target Name | PCID2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 2-399 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q5JVF3 |
|---|
Uniprot Id
Q5JVF3
Target Species
Human
Target Name
PCID2
Target Full Name
PCI domain-containing protein 2
Target Function
Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (Probable). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.
Target Subcellular Location
Cytoplasm. Nucleus, nuclear pore complex.
Target Protein Families
CSN12 family
Target Synonyms
CSN12 like protein; CSN12-like protein; DKFZp686C20226; F10; FLJ11305; FLJ99362; HT004; MGC16774; PCI domain containing 2; PCI domain containing protein 2; PCI domain-containing protein 2; PCID2; PCID2_HUMAN; RP11 - 98F14.6
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