Recombinant Human PDZ and LIM domain protein 3 (PDLIM3)

Uniprot Id

Q53GG5

Target Species

Human

Target Name

PDLIM3

Target Full Name

PDZ and LIM domain protein 3

Target Function

May play a role in the organization of actin filament arrays within muscle cells.

Target Subcellular Location

Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to myofiber Z-lines.

Target Tissue Specificity

Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.

Target Research Area

Signal Transduction

Target Synonyms

Actinin associated LIM protein; Actinin-associated LIM protein; Alpha actinin 2 associated LIM protein; Alpha-actinin-2-associated LIM protein; DKFZp686L0362; Enigma homolog; PDLI3_HUMAN; PDLIM 3; PDLIM3; PDZ and LIM domain 3; PDZ and LIM domain protein 3

Target Background

The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy.