Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
| Cat.No | ACP18561 | Target Name | PJVK |
|---|---|---|---|
| Target Synonyms | Autosomal recessive deafness type 59 protein; DFNB59; DFNB59 deafness; autosomal recessive 59; Pejvakin; PJVK ; PJVK_HUMAN | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-352 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q0ZLH3 |
|---|
Uniprot Id
Q0ZLH3
Target Species
Human
Target Name
PJVK
Target Full Name
Pejvakin
Target Function
Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation
Target Involvement
Deafness, autosomal recessive, 59 (DFNB59)
Target Subcellular Location
Peroxisome membrane. Cell projection, cilium.
Target Protein Families
Gasdermin family
Target Synonyms
Autosomal recessive deafness type 59 protein; DFNB59; DFNB59 deafness; autosomal recessive 59; Pejvakin; PJVK ; PJVK_HUMAN
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
