Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP2 (FKBP2)

Uniprot Id

P26885

Target Species

Human

Target Name

FKBP2

Target Full Name

Peptidyl-prolyl cis-trans isomerase FKBP2

Target Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Target Subcellular Location

Endoplasmic reticulum membrane; Peripheral membrane protein.

Target Protein Families

FKBP-type PPIase family, FKBP2 subfamily

Target Tissue Specificity

T-cells and thymus.

Target Synonyms

13 kDa FK506-binding protein; 13 kDa FKBP; EC 5.2.1.8; FK506 binding protein 2 (13kD) ; FK506 binding protein 2 13kDa; FK506-binding protein 2; FK506-binding protein; T-cell; 13-KD; FKBP 13; FKBP 2 ; FKBP-13; FKBP-2; FKBP13; FKBP2; FKBP2_HUMAN; Immunophilin FKBP13; Peptidyl prolyl cis trans isomerase ; Peptidyl-prolyl cis-trans isomerase FKBP2; PPIase; PPIase FKBP2; Proline isomerase ; Rapamycin binding protein ; Rotamase

Target Background

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified.