Recombinant Human Perilipin-2 (PLIN2)

Uniprot Id

Q99541

Target Species

Human

Target Name

PLIN2

Target Full Name

Perilipin-2

Target Function

May be involved in development and maintenance of adipose tissue.

Target Subcellular Location

Membrane; Peripheral membrane protein. Lipid droplet.

Target Protein Families

Perilipin family

Target Tissue Specificity

Milk lipid globules.

Target Synonyms

ADFP; Adipophilin; Adipose differentiation related protein; Adipose differentiation-related protein; ADRP; MGC10598; Perilipin-2; PLIN2; PLIN2_HUMAN

Target Background

The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene.