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| Cat.No | ACP11548 | Target Name | PDCL3 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-239 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9H2J4 |
|---|
Uniprot Id
Q9H2J4
Target Species
Human
Target Name
PDCL3
Target Full Name
Phosducin-like protein 3
Target Function
Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes. Modulates the activation of caspases during apoptosis.
Target Subcellular Location
Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum.
Target Protein Families
Phosducin family
Target Tissue Specificity
Expressed in endothelial cells (at protein level). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon.
Target Synonyms
HTPHLP; IAP associated factor VIAF1; MGC3062; PDCL 3; Pdcl3; PDCL3_HUMAN; PHLP2A; PHLP3; Phosducin like 3; Phosducin like protein 3; Phosducin-like protein 3; PhPL3; VIAF 1; VIAF; VIAF-1; VIAF1; Viral IAP associated factor 1; Viral IAP-associated factor 1
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