Recombinant Human Phosphatidylcholine:ceramide cholinephosphotransferase 1 (SGMS1), Truncated

Uniprot Id

Q86VZ5

Target Species

Human

Target Name

SGMS1

Target Full Name

Phosphatidylcholine:ceramide cholinephosphotransferase 1

Target Function

Major sphingomyelin synthase at the Golgi apparatus. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes. Does not use free phosphorylcholine or CDP-choline as donor. Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting. Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1.

Target Subcellular Location

Golgi apparatus membrane; Multi-pass membrane protein.

Target Protein Families

Sphingomyelin synthase family

Target Tissue Specificity

Brain, heart, kidney, liver, muscle and stomach.

Target Synonyms

SGMS1; MOB; SMS1; TMEM23; Phosphatidylcholine:ceramide cholinephosphotransferase 1; Medulla oblongata-derived protein; Protein Mob; Sphingomyelin synthase 1; Transmembrane protein 23

Target Background

The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain.