Recombinant Human Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (PIGQ), Truncated

Uniprot Id

Q9BRB3

Target Species

Human

Target Name

PIGQ

Target Full Name

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

Target Function

Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis.

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

PIGQ family

Target Synonyms

PIGQ; GPI1; Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q; N-acetylglucosamyl transferase component GPI1; Phosphatidylinositol-glycan biosynthesis class Q protein; PIG-Q

Target Background

This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.