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This Human PGM1 recombinant protein was produced in E. coli, where the gene sequence encoding Human PGM1 (1-562aa) was expressed with the N-terminal 6xHis-SUMO tag. The purity of this PGM1 protein was greater than 90% by SDS-PAGE.PGM1 is an enzyme with the primary function of catalyzing the interconversion of glucose-6-phosphate (G6P) and glucose-1-phosphate (G1P) in the sugar metabolism pathway. Specifically, it converts G6P to G1P or G1P to G6P. This enzymatic activity is crucial for cellular energy metabolism and the synthesis and breakdown of sugars. PGM1 is involved in multiple sugar metabolism pathways, including sugar isomerization, sugar alcohol phosphorylation, and glycogen synthesis and breakdown. These pathways are essential for maintaining cellular energy balance and survival.The PGM1 gene is located in the human genome, and mutations or genetic variations can lead to a rare inherited metabolic disorder known as PGM1 deficiency disease (PGM1-CDG). This is a glycoprotein glycosylation disorder, and patients typically exhibit multisystem symptoms, including growth retardation, neurological issues, and immune system problems.
This Human PGM1 recombinant protein was produced in E. coli, where the gene sequence encoding Human PGM1 (1-562aa) was expressed with the N-terminal 6xHis-SUMO tag. The purity of this PGM1 protein was greater than 90% by SDS-PAGE.PGM1 is an enzyme with the primary function of catalyzing the interconversion of glucose-6-phosphate (G6P) and glucose-1-phosphate (G1P) in the sugar metabolism pathway. Specifically, it converts G6P to G1P or G1P to G6P. This enzymatic activity is crucial for cellular energy metabolism and the synthesis and breakdown of sugars. PGM1 is involved in multiple sugar metabolism pathways, including sugar isomerization, sugar alcohol phosphorylation, and glycogen synthesis and breakdown. These pathways are essential for maintaining cellular energy balance and survival.The PGM1 gene is located in the human genome, and mutations or genetic variations can lead to a rare inherited metabolic disorder known as PGM1 deficiency disease (PGM1-CDG). This is a glycoprotein glycosylation disorder, and patients typically exhibit multisystem symptoms, including growth retardation, neurological issues, and immune system problems.
| Cat.No | ACP03962 | Target Name | PGM1 |
|---|---|---|---|
| Target Synonyms | CDG1T; Glucose phosphomutase 1; GSD14; OTTHUMP00000010519; OTTHUMP00000010520; PGM 1; PGM1; PGM1_HUMAN; Phosphoglucomutase 1; Phosphoglucomutase-1; Phosphoglucomutase1 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-562aa |
| Mol Weight | 77.4kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P36871 |
|---|
Uniprot Id
P36871
Target Species
Human
Target Name
PGM1
Target Full Name
Phosphoglucomutase-1
Target Function
This enzyme participates in both the breakdown and synthesis of glucose.
Target Involvement
Congenital disorder of glycosylation 1T (CDG1T)
Target Subcellular Location
[Isoform 1]: Cytoplasm.
Target Protein Families
Phosphohexose mutase family
Target Research Area
Metabolism
Target Synonyms
CDG1T; Glucose phosphomutase 1; GSD14; OTTHUMP00000010519; OTTHUMP00000010520; PGM 1; PGM1; PGM1_HUMAN; Phosphoglucomutase 1; Phosphoglucomutase-1; Phosphoglucomutase1
Target Background
The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.
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