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| Cat.No | ACP18626 | Target Name | PLA1A |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 26-456 | Protein Length | Full Length of Mature Protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q53H76 |
|---|
Uniprot Id
Q53H76
Target Species
Human
Target Name
PLA1A
Target Full Name
Phospholipase A1 member A
Target Function
Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling. Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production. Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein.; Hydrolyzes lyso-PS but not PS.
Target Subcellular Location
Secreted.
Target Protein Families
AB hydrolase superfamily, Lipase family
Target Tissue Specificity
Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney.
Target Synonyms
AA986889; NMD; OTTHUMP00000215248; OTTHUMP00000215249; OTTHUMP00000215250; Phosphatidylserine specific phospholipase A1; Phosphatidylserine specific phospholipase A1alpha; Phosphatidylserine-specific phospholipase A1; Phospholipase A1 member A; pla1a; PLA1A_HUMAN; PS PLA1; PS-PLA1; PSPLA 1; PSPLA1
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