Recombinant Human Phospholipase B1, membrane-associated (PLB1), Truncated

Uniprot Id

Q6P1J6

Target Species

Human

Target Name

PLB1

Target Full Name

Phospholipase B1, membrane-associated

Target Function

Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates. Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity. May also hydrolyze long chain retinyl esters such as retinyl palmitate. May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border

Target Subcellular Location

Apical cell membrane; Single-pass type I membrane protein.

Target Protein Families

'GDSL' lipolytic enzyme family, Phospholipase B1 subfamily

Target Tissue Specificity

Expressed in the epidermis (at protein level).

Target Synonyms

PLB1; PLB; Phospholipase B1; membrane-associated; Phospholipase B; hPLB; Phospholipase B/lipase; PLB/LIP) [Includes: Phospholipase A2; EC 3.1.1.4); Lysophospholipase; EC 3.1.1.5)]