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| Cat.No | ACP20535 | Target Name | DDHD2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-711 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O94830 |
|---|
Uniprot Id
O94830
Target Species
Human
Target Name
DDHD2
Target Full Name
Triacylglycerol hydrolase DDHD2
Target Function
Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane.
Target Involvement
Spastic paraplegia 54, autosomal recessive (SPG54)
Target Subcellular Location
Cytoplasm, cytosol. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Cycles between the Golgi apparatus and the cytosol. DDHD2 recruitment to the Golgi/endoplasmic reticulum-Golgi intermediate compartment (ERGIC) is regulated by the levels of phosphoinositides, including PI(4)P.
Target Protein Families
PA-PLA1 family
Target Tissue Specificity
Widely expressed (at protein level).
Target Synonyms
DDHD domain containing protein 2; DDHD domain-containing protein 2; Ddhd2; DDHD2_HUMAN; KIAA0725; mKIAA0725; Phospholipase DDHD2; SAM; SAM; WWE and DDHD domain containing protein 1; SAMWD1; WWE and DDHD domain-containing protein 1
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