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This Human PLTP recombinant protein was produced in E.coli, where the gene sequence encoding Human PLTP (18-493aa) was expressed with the N-terminal GST tag. The purity of this PLTP protein was greater than 90% by SDS-PAGE.One of the primary functions of PLTP is to facilitate the transfer of different categories of lipids, such as phospholipids and triglycerides, between various lipid carriers. Specifically, it promotes lipid transfer between high-density lipoprotein (HDL) and low-density lipoprotein (LDL), which is essential for maintaining lipid balance in the bloodstream. PLTP plays a crucial role in lipid metabolism. It helps clear excess cholesterol from the body and facilitates the return of cholesterol from peripheral tissues to the liver, contributing to cardiovascular health. Additionally, PLTP is involved in the repair and maintenance of cell membranes, which is essential for preserving cell integrity.Aberrant activity or expression of PLTP is associated with some diseases. For instance, insufficient PLTP activity can lead to disruptions in cholesterol metabolism, increasing the risk of cardiovascular diseases. Furthermore, PLTP is linked to the pathogenesis of conditions like obesity, metabolic syndrome, and diabetes.
This Human PLTP recombinant protein was produced in E.coli, where the gene sequence encoding Human PLTP (18-493aa) was expressed with the N-terminal GST tag. The purity of this PLTP protein was greater than 90% by SDS-PAGE.One of the primary functions of PLTP is to facilitate the transfer of different categories of lipids, such as phospholipids and triglycerides, between various lipid carriers. Specifically, it promotes lipid transfer between high-density lipoprotein (HDL) and low-density lipoprotein (LDL), which is essential for maintaining lipid balance in the bloodstream. PLTP plays a crucial role in lipid metabolism. It helps clear excess cholesterol from the body and facilitates the return of cholesterol from peripheral tissues to the liver, contributing to cardiovascular health. Additionally, PLTP is involved in the repair and maintenance of cell membranes, which is essential for preserving cell integrity.Aberrant activity or expression of PLTP is associated with some diseases. For instance, insufficient PLTP activity can lead to disruptions in cholesterol metabolism, increasing the risk of cardiovascular diseases. Furthermore, PLTP is linked to the pathogenesis of conditions like obesity, metabolic syndrome, and diabetes.
| Cat.No | ACP04747 | Target Name | PLTP |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 18-493aa | Mol Weight | 80.1kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P55058 |
|---|
Uniprot Id
P55058
Target Species
Human
Target Name
PLTP
Target Full Name
Phospholipid transfer protein
Target Function
Mediates the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low density lipoproteins or LDL and very low density lipoproteins or VLDL) into high-density lipoproteins (HDL) as well as the exchange of phospholipids between triglyceride-rich lipoproteins themselves. Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylinositol, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Plays an important role in HDL remodeling which involves modulating the size and composition of HDL. Also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer phosphatidylcholine from phospholipid vesicles to HDL, and an inactive form that lacks this capability.
Target Subcellular Location
Secreted. Nucleus.
Target Protein Families
BPI/LBP/Plunc superfamily, BPI/LBP family
Target Tissue Specificity
Widely expressed. Highest level of expression in the ovary, thymus and placenta, with moderate levels found in the pancreas, small intestine, testis, lung and prostrate. Low level expression in the kidney, liver and spleen, with very low levels found in t
Target Research Area
Transport
Target Synonyms
BPI fold containing family E; BPIFE; HDLCQ9; High density lipoprotein cholesterol level quantitative trait locus 9; included; Lipid transfer protein II; OD107; Phospholipid transfer protein; Plasma phospholipid transfer protein ; Pltp; PLTP_HUMAN
Target Background
The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.
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