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| Cat.No | ACP10321 | Target Name | PPCS |
|---|---|---|---|
| Target Synonyms | COAB; FLJ11838; MGC117357; MGC138220; OTTHUMP00000008433; Phosphopantothenate--cysteine ligase; Phosphopantothenoylcysteine synthetase; PPC synthetase; Ppcs; PPCS_HUMAN; RP11-163G10.1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 2-311 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9HAB8 |
|---|
Uniprot Id
Q9HAB8
Target Species
Human
Target Name
PPCS
Target Full Name
Phosphopantothenate--cysteine ligase
Target Function
Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. Has a preference for ATP over CTP as a cosubstrate.
Target Protein Families
PPC synthetase family
Target Synonyms
COAB; FLJ11838; MGC117357; MGC138220; OTTHUMP00000008433; Phosphopantothenate--cysteine ligase; Phosphopantothenoylcysteine synthetase; PPC synthetase; Ppcs; PPCS_HUMAN; RP11-163G10.1
Target Background
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).
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