Recombinant Human Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (PHKG1)

Uniprot Id

Q16816

Target Species

Human

Target Name

PHKG1

Target Full Name

Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

Target Function

Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3.

Target Protein Families

Protein kinase superfamily, CAMK Ser/Thr protein kinase family

Target Synonyms

PHK gamma M; PHK-gamma-M; Phkg; PHKG1; PHKG1_HUMAN; PHKIN01; Phosphorylase b kinase gamma catalytic chain; Phosphorylase b kinase gamma catalytic chain skeletal muscle/heart isoform; phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform ; phosphorylase kinase gamma ; phosphorylase kinase subunit gamma 1 ; Phosphorylase kinase subunit gamma-1; phosphorylase kinase, gamma 1 (muscle); Phosphorylase kinase, muscle, gamma-1; Serine/threonine-protein kinase PHKG1; skeletal muscle/heart isoform

Target Background

This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12. Multiple transcript variants encoding different isoforms have been found for this gene.