Recombinant Human Phosphoserine phosphatase (PSPH)

Uniprot Id

P78330

Target Species

Human

Target Name

PSPH

Target Full Name

Phosphoserine phosphatase

Target Function

Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L-serine to L-serine. L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator. May also act on O-phospho-D-serine (Probable).

Target Involvement

Phosphoserine phosphatase deficiency (PSPHD)

Target Subcellular Location

Cytoplasm, cytosol.

Target Protein Families

HAD-like hydrolase superfamily, SerB family

Target Research Area

Signal Transduction

Target Synonyms

EC 3.1.3.3; L 3 phosphoserine phosphatase; L-3-phosphoserine phosphatase; O phosphoserine phosphohydrolase; O-phosphoserine phosphohydrolase; Phosphoserine phosphatase; Phosphoserine phosphatase deficiency; included; PSP; PSPase; Psph; PSPHD; SERB_HUMAN

Target Background

The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome.