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The recombinant Human SERPINB2 protein is encoded by the gene of SERPINB2 (1-415aa). The gene of SERPINB2 was cloned in a system (Mammalian cell) that supported the expression of SERPINB2 and translation of messenger RNA. Modification of SERPINB2 by recombinant DNA technology could lead to the expression of the target protein. The protein was fused with N-terminal 10xHis tag in the production. The purity is 85% determined by SDS-PAGE.SerpinB2 (PAI2) is a protein coding gene that encodes Plasminogen activator inhibitor 2. According to some studies, SerpinB2 may have the following features.Regulating Th1 response seems to be a physiological function of inflammation-related SerpinB2. One function of SerpinB2 is to sculpt the adaptive immune response. SerpinB2 regulates the stroma remodeling and local invasion of pancreatic cancer. SerpinB2 protects retinoblastoma protein from the influence of calcin and enhances the viability of tumor cells. The Kindlin2-p53-SerpinB2 signal axis is necessary for breast cancer cell senescence. The serine protease inhibitor SerpinB2 binds and stabilizes p21 in senescent cells. SerpinB2 inhibits migration and promotes the resolution phase characteristics of large peritoneal macrophages. SerpinB2 expressed by tumor cells is present on the microparticles and inhibits metastasis. SERPINB2 is a new indicator of stem cell toxicity.
The recombinant Human SERPINB2 protein is encoded by the gene of SERPINB2 (1-415aa). The gene of SERPINB2 was cloned in a system (Mammalian cell) that supported the expression of SERPINB2 and translation of messenger RNA. Modification of SERPINB2 by recombinant DNA technology could lead to the expression of the target protein. The protein was fused with N-terminal 10xHis tag in the production. The purity is 85% determined by SDS-PAGE.SerpinB2 (PAI2) is a protein coding gene that encodes Plasminogen activator inhibitor 2. According to some studies, SerpinB2 may have the following features.Regulating Th1 response seems to be a physiological function of inflammation-related SerpinB2. One function of SerpinB2 is to sculpt the adaptive immune response. SerpinB2 regulates the stroma remodeling and local invasion of pancreatic cancer. SerpinB2 protects retinoblastoma protein from the influence of calcin and enhances the viability of tumor cells. The Kindlin2-p53-SerpinB2 signal axis is necessary for breast cancer cell senescence. The serine protease inhibitor SerpinB2 binds and stabilizes p21 in senescent cells. SerpinB2 inhibits migration and promotes the resolution phase characteristics of large peritoneal macrophages. SerpinB2 expressed by tumor cells is present on the microparticles and inhibits metastasis. SERPINB2 is a new indicator of stem cell toxicity.
| Cat.No | ACP02426 | Target Name | SERPINB2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Mammalian cell |
| Expression Range | 1-415aa | Mol Weight | 50.1 kDa |
| Protein Length | Full length | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P05120 |
|---|
Uniprot Id
P05120
Target Species
Human
Target Name
SERPINB2
Target Full Name
Plasminogen activator inhibitor 2
Target Function
Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.
Target Subcellular Location
Cytoplasm. Secreted, extracellular space.
Target Protein Families
Serpin family, Ov-serpin subfamily
Target Research Area
Cell Biology
Target Synonyms
HsT1201; Monocyte Arg serpin ; Monocyte Arg-serpin; Monocyte Arginine-serpin; Monocyte-derived plasminogen activator inhibitor; PAI; PAI-2; PAI2 ; PAI2_HUMAN; Placental plasminogen activator inhibitor; PLANH2 ; Plasminogen activator inhibitor 2; plasminogen activator inhibitor; type 2; plasminogen activator inhibitor; type II (arginine-serpin); serine (or cysteine) proteinase inhibitor; clade B (ovalbumin); member 2; Serpin B2; serpin peptidase inhibitor; clade B (ovalbumin); member 2; Serpinb2; Urokinase inhibitor
Target Background
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space.
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