Recombinant Human Plastin-2 (LCP1)

E.coli-expressed recombinant Plastin-2 (LCP1) is a full-length of mature protein carrying an N-terminal 6xHis-SUMO-tag. It contains amino acid 2-627 of human LCP1 protein and has a predicted molecular mass of 86.2 kDa. Its purity is up to 90% as determined by SDS-PAGE. This recombinant LCP1 protein may discover uses in the studies of LCP1-related cancers or as an immunogen for antibody synthesis. This protein in-stock is available. LCP1, a.k.a. leukocyte plastin/L-plastin, is an actin-bundling protein exclusively expressed in hematopoietic and cancer cell lineages. In addition to involvement in both innate immunity and adaptive immunity, LCP1 has been detected significantly up-regulated in many cancer cell lineages and is correlated to cancer invasion and metastasis. LCP1 thus can serve as a common marker of many types of human cancer.

ACP02589

E.coli-expressed recombinant Plastin-2 (LCP1) is a full-length of mature protein carrying an N-terminal 6xHis-SUMO-tag. It contains amino acid 2-627 of human LCP1 protein and has a predicted molecular mass of 86.2 kDa. Its purity is up to 90% as determined by SDS-PAGE. This recombinant LCP1 protein may discover uses in the studies of LCP1-related cancers or as an immunogen for antibody synthesis. This protein in-stock is available.
LCP1, a.k.a. leukocyte plastin/L-plastin, is an actin-bundling protein exclusively expressed in hematopoietic and cancer cell lineages. In addition to involvement in both innate immunity and adaptive immunity, LCP1 has been detected significantly up-regulated in many cancer cell lineages and is correlated to cancer invasion and metastasis. LCP1 thus can serve as a common marker of many types of human cancer.

Number

Cat.No	ACP02589	Target Name	LCP1
Target Synonyms	CP64; L plastin; L-plastin; Larval cuticle protein 1; LC64P; LCP-1; LCP1; LPL; Lplastin; Lymphocyte cytosolic protein 1; Plastin 2; Plastin-2; PLS2; PLSL_HUMAN	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	2-627aa
Mol Weight	86.2kDa	Protein Length	Full Length of Mature Protein
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02589

Target Name

LCP1

Target Synonyms

CP64; L plastin; L-plastin; Larval cuticle protein 1; LC64P; LCP-1; LCP1; LPL; Lplastin; Lymphocyte cytosolic protein 1; Plastin 2; Plastin-2; PLS2; PLSL_HUMAN

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

2-627aa

Mol Weight

86.2kDa

Protein Length

Full Length of Mature Protein

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P13796

Background Information

Uniprot Id

P13796
Target Species

Human
Target Name

LCP1
Target Full Name

Plastin-2
Target Function

Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.
Target Involvement

Chromosomal aberrations involving LCP1 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;13)(q27;q14), with BCL6.
Target Subcellular Location

Cytoplasm, cytoskeleton. Cell junction. Cell projection. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side.
Target Tissue Specificity

Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.
Target Research Area

Cancer
Target Synonyms

CP64; L plastin; L-plastin; Larval cuticle protein 1; LC64P; LCP-1; LCP1; LPL; Lplastin; Lymphocyte cytosolic protein 1; Plastin 2; Plastin-2; PLS2; PLSL_HUMAN
Target Background

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.

Recombinant Human Plastin-2 (LCP1)

Specifications

Immunogen Information

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