Recombinant Human Plastin-3 (PLS3)

Uniprot Id

P13797

Target Species

Human

Target Name

PLS3

Target Full Name

Plastin-3

Target Function

Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.

Target Involvement

Osteoporosis (OSTEOP)

Target Subcellular Location

Cytoplasm.

Target Tissue Specificity

Expressed in a variety of organs, including muscle, brain, uterus and esophagus.

Target Synonyms

BMND18; Plastin 3 (T isoform); Plastin 3; Plastin-3; PLS3; PLST_HUMAN; T fimbrin; T-plastin

Target Background

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.