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This Recombinant Human PDGFB is a powerful research tool for investigating the role of Platelet-derived growth factor subunit B (PDGF subunit B) in metabolism. PDGFB plays a vital role in various biological processes, including cell growth, proliferation, and angiogenesis, making it an essential protein to study for a deeper understanding of metabolic pathways. This Recombinant Human PDGFB features the full length of the mature protein (82-190aa), ensuring accurate representation for your research endeavors. Expressed in E. coli, the protein carries a C-terminal 6xHis tag, facilitating easy purification and detection. With a purity of greater than 90% as determined by SDS-PAGE, and available in both liquid and lyophilized powder forms, this high-quality recombinant protein offers the performance and reliability required for your metabolism-focused research projects.
This Recombinant Human PDGFB is a powerful research tool for investigating the role of Platelet-derived growth factor subunit B (PDGF subunit B) in metabolism. PDGFB plays a vital role in various biological processes, including cell growth, proliferation, and angiogenesis, making it an essential protein to study for a deeper understanding of metabolic pathways.
This Recombinant Human PDGFB features the full length of the mature protein (82-190aa), ensuring accurate representation for your research endeavors. Expressed in E. coli, the protein carries a C-terminal 6xHis tag, facilitating easy purification and detection. With a purity of greater than 90% as determined by SDS-PAGE, and available in both liquid and lyophilized powder forms, this high-quality recombinant protein offers the performance and reliability required for your metabolism-focused research projects.
| Cat.No | ACP02609 | Target Name | PDGFB |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 82-190aa | Mol Weight | 14.3 kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P01127 |
|---|
Uniprot Id
P01127
Target Species
Human
Target Name
PDGFB
Target Full Name
Platelet-derived growth factor subunit B
Target Function
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA.
Target Involvement
Basal ganglia calcification, idiopathic, 5 (IBGC5)
Target Subcellular Location
Secreted. Note=Released by platelets upon wounding.
Target Protein Families
PDGF/VEGF growth factor family
Target Tissue Specificity
Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.
Target Research Area
Cancer
Target Synonyms
Becaplermin; c sis; FLJ12858; Oncogene SIS; PDGF 2; PDGF B chain; PDGF Beta; PDGF subunit B; PDGF-2; PDGF2; Pdgfb; PDGFB_HUMAN; Platelet derived growth factor 2; Platelet derived growth factor B chain; Platelet derived growth factor beta; Platelet derived growth factor beta polypeptide (oncogene SIS); Platelet derived growth factor beta polypeptide (simian sarcoma viral (v sis) oncogene homolog); Platelet derived growth factor beta polypeptide; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Platelet-derived growth factor subunit B; Proto-oncogene c-Sis; Simian sarcoma viral (v sis) oncogene homolog; SIS; SSV; v sis platelet derived growth factor beta polypeptide
Target Background
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants.
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