Recombinant Human Pleckstrin homology domain-containing family A member 8 (PLEKHA8)

Uniprot Id

Q96JA3

Target Species

Human

Target Name

PLEKHA8

Target Full Name

Pleckstrin homology domain-containing family A member 8

Target Function

Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.

Target Subcellular Location

Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein.

Target Tissue Specificity

Expressed in kidney cell lines.

Target Synonyms

FAPP-2; FAPP2; hFAPP2; MGC3358; PH domain-containing family A member 8; Phosphatidylinositol-four-phosphate adapter protein 2; Phosphoinositide binding specificmember 8 ; Phosphoinositol 4 phosphate adaptor protein 2; Phosphoinositol 4-phosphate adapter protein 2; PKHA8_HUMAN; Pleckstrin homology domain containing A8; Pleckstrin homology domain containing family A (Phosphoinositide binding specific) member 8; Pleckstrin homology domain containing family A; Pleckstrin homology domain-containing family A member 8; Plekha8; PLEKHA8 protein ; Serologically defined breast cancer antigen NY-BR-86