Recombinant Human Plexin-A1 (PLXNA1), Truncated

Uniprot Id

Q9UIW2

Target Species

Human

Target Name

PLXNA1

Target Full Name

Plexin-A1

Target Function

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Protein Families

Plexin family

Target Tissue Specificity

Detected in fetal brain, lung, liver and kidney.

Target Research Area

Neuroscience

Target Synonyms

PLXNA1; NOV; PLXN1; Plexin-A1; Semaphorin receptor NOV

Target Background

Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including generation of neurons; regulation of GTPase activity; and regulation of cell shape. Predicted to act upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching; neuron projection morphogenesis; and regulation of smooth muscle cell migration. Located in cytosol and nucleoplasm.