Recombinant Human Plexin-A2 (PLXNA2), Truncated

Uniprot Id

O75051

Target Species

Human

Target Name

PLXNA2

Target Full Name

Plexin-A2

Target Function

Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Protein Families

Plexin family

Target Tissue Specificity

Detected in fetal brain.

Target Synonyms

Plexin-A2; PlexinA2 ; PLXA2; PLXA2_HUMAN; PLXNA2; Semaphorin receptor OCT

Target Background

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.